In 2374, Captain Benjamin Sisko arguably committed a major Prime Directive violation when he worked with Elim Garak to force the Romulan Empire to enter into Dominion War under false pretenses. The Romulans up to this point had remained neutral in the conflict. Sisko felt that Federation and Klingon Empire would lose the war with the Dominion if they did not gain another ally in the war. Both Sisko and Garak, with the knowledge and approval of Starfleet Command, created false evidence that ultimately convinced the Romulans that the Dominion were planning to renage on the Peace Treaty between the two governments and mount a full scale invasion. Participation in the war resulted in massive military and civilian casualties, and likely resulted in major economic, political, military and social shifts for the Romulan Society. But for Sisko's intervention, the Romulans may not have suffered such consequences.
It should be noted that since Sisko erased the log entry in which he admitted his actions, there is no official record of this incident occuring. That, coupled with the fact that Sisko carried out this mission with Starfleet's blessings resulted in Sisko facing no consequences whatsoever for his deception. Apparently, Starfleet Command is willing to overlook the Prime Directive when the Federation is in a state of interstellar war. (In The Pale Moonlight)
Number6 said:
Well... Allowing an entire race to worship him as the Emisary to their Prophets was a major violation from the get-go.
There are countless other violations.
Admiral Valeris said:
^But Starfleet allows for the destruction of a planet or civilization through General Order 24.
So it's reprehensible and abhorrent, but under certain circumstances justifiable.
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