How about a Trek show that isn't focused on Starfleet people?
ST:RSO-- Star Trek: Rogue Star One
Stuck in the middle of a great expanse between two of the galaxy's spiral arms, way out in the middle of freaking nowhere, lies an ancient rogue white dwarf surrounded by a few long-dead planets. In orbit around one of those planets is an impossibly old space station, put there by... well, nobody knows.
Discovered about 25 years prior, the station had since been revamped and expanded by a Ferengi company looking to profit from tourism and scientists. That company went broke, and through some slick chicanery, the crew of the station managed to gain ownership of it. They may or may not owe the Orion Syndicate a lot of money. They aren't Ferengi, except for one guy. They are a mix of people, mostly human or human-ish, and are far, FAR from the kinds of people we have always known among Starfleet's Finest. No, they aren't scuzzballs or anything, but they are pretty much people like we 21st century types.
I'm thinking the Commander is a Vince Vaughn/ Joe Everyman sort of guy.
Today, the station is always abuzz with activity.
The original station was originally built, so very long ago, to study the long lost civilization of the planets, and now the trend continues. Scientists are constantly getting underfoot as they study the planets and the station itself. Even better, the fact that there are no other stars around gives the station's telescopes a fantastically clear view. It can see things in intergalactic space, and sometimes it does! The station's old memory banks have stored some data gathered by it's telescopes in the early days, and something VERY disturbing and perplexing has been learned.
The scientists aren't the only visitors.
Along the edges of the expanse, scattered through the galactic arms, are many civilizations of limited warp capacity. Getting across the gap is a difficult thing to do. However, now they can stop at RSO at roughly the halfway point for rest, repairs, etc...
In short, RSO is a truckstop in space.
It's also a big brokerage house and meeting spot. Traders don't have to go all the way across the gap anymore. They can instead just meet with their trading partners halfway or even pick up/drop off their loads at the station.
This gives us a lot of plot opportunities, as each week we have people coming and going.
The station is also a repair depot, so broken down ships can call for help and get towed in by the station's more advanced vessels.
Of course, broken ships usually indicate plot-hooks.
The station is also the only bastion of law & order out in the gap, so the station frequently gets called upon to send out a ship to help solve some sort of problem. ( the fact that RSO's crew are themselves the biggest criminal element in the gap is something we'll try to ignore LOL!!! )
The old part of the station, the core, is very creepy. The new parts are all shiny and clean, but the old parts are anything but that. A bit like a truckstop, yes, when one goes from the touristy parts in the front and walks out back to the garage. However, dust and grime are only cosmetic. No, there is something else going on here, something downright weird and creepy. It's like it's haunted, or worse yet...somehow....alive.
Over time, we watch the guys who work in the core section start acting more & more strangely. It's like they are becoming aliens. They start using an odd slang among themselves, their personalities shift, and they become wizards at working with the old technology which previously confounded them.
Yep, ST:RSO could be a great show.