I like to think at some point the Earth-1 version of Kara will show up and in the absence of Clark becomes Power Girl. I also rather like the idea that Earth-1's Superman landed pre-1939 like in the very first comics, making him a contemporary of Amaya. He'd still be alive and well in present day (if a little grey) but has long since put away the cape.
Or perhaps in this universe Kal-El's ship was the one trapped in the phantom zone for a decade or two and didn't make it to Earth until much later than his Earth-38 counterpart. Another possibility is that both he and Kara are on Earth already, but keeping a low profile, just like Bruce Wayne.
That's not irony, it just means he has a better agent than anyone else.