This is a subject that refuses to die, which is a good thing for it makes for lively discussion and stretching of the mental muscles.
One could also make the case that it has real world parallels in history and potentially for the future.
The Prime Directive didn't just spring into being (within the context of the Trek universe) out of the goodness and well meaning intentions of Federation hearts. It's a policy that would have been endlessly debated and argued before finally being drafted and implemented.
The various races that make up the Federation must all at one time or another encountered other cultures and dealt with the subsequent encounters and results each in their own way. And after coming together to form the UFP they eventually agreed to a common code of conduct in regard to dealing with newly encountered cultures. That said various contingencies must have applied to cultures already encountered before the Prime Directive was adopted.
In TOS we get some idea that cultural study is conducted on some covert or unobtrusive level so as not to upset or corrupt a planet's normal development. We also see this in TNG. There are evidently rules in place while conducting such studies.
Which leads me to the thought that perhaps some incidents of past cultural observing might not have gone so well and contributed to the development of the Prime Directive. Granted I'm not that well versed in the ENT episodes, but it seems to me that there could be at least a couple of good prequel stories to be told regarding the wisdom (or lack thereof) in interfering with a less advanced culture's development. The other aspect of the Prime Directive regarding non-interference in a Federation member world's or other advanced society's internal workings is likely a result of legislated self-interest---don't stick your nose in my personal affairs and I won't stick my nose in yours. This parallels much of what we see going on around us all the time in terms of relations between nations.
So I'm more interested in how the Prime Directive might have come into being in regards to non-interference in the normal development of newly encountered cultures. What sort of things could have led to the Federation adopting such a policy?

The Prime Directive didn't just spring into being (within the context of the Trek universe) out of the goodness and well meaning intentions of Federation hearts. It's a policy that would have been endlessly debated and argued before finally being drafted and implemented.
The various races that make up the Federation must all at one time or another encountered other cultures and dealt with the subsequent encounters and results each in their own way. And after coming together to form the UFP they eventually agreed to a common code of conduct in regard to dealing with newly encountered cultures. That said various contingencies must have applied to cultures already encountered before the Prime Directive was adopted.
In TOS we get some idea that cultural study is conducted on some covert or unobtrusive level so as not to upset or corrupt a planet's normal development. We also see this in TNG. There are evidently rules in place while conducting such studies.
Which leads me to the thought that perhaps some incidents of past cultural observing might not have gone so well and contributed to the development of the Prime Directive. Granted I'm not that well versed in the ENT episodes, but it seems to me that there could be at least a couple of good prequel stories to be told regarding the wisdom (or lack thereof) in interfering with a less advanced culture's development. The other aspect of the Prime Directive regarding non-interference in a Federation member world's or other advanced society's internal workings is likely a result of legislated self-interest---don't stick your nose in my personal affairs and I won't stick my nose in yours. This parallels much of what we see going on around us all the time in terms of relations between nations.
So I'm more interested in how the Prime Directive might have come into being in regards to non-interference in the normal development of newly encountered cultures. What sort of things could have led to the Federation adopting such a policy?