This prequel is going to try to answer a question due to an episode of - "chronologically to their calendar, not as of date of production", some 2 TV
series later technically made several decades prior - that created the invading malignancy and then dropped it? The same malignancy that nobody knew about? (So is the species being introduced going to just create the invading neon purple shellfish? Two things to that:
1. Wouldn't it be more fun to watch the mystery unfold in the original TNG episodes unfold without being spoonfed this "answering in advance", so to speak? Naah. IMHO I wish PIC3 (or "Legacy" if that were to take off) had answered it and closed it instead of the Borg, but for other reasons bringing back the Borg made a certain sense despite their massive overuse. (Keeping in mind scripting deadlines and such, and how Season 1 TNG was not well-received so unless they had a big reason**, they avoided it.)
2. Given the few attempts to line up with (here it comes) continuity where it mattered, why does it matter now? Will it matter? Will viewers care either way? Will it stick out so badly?
All this aside, the idea that another species created the shellfish things that invaded 100-whatever years later (same timeline or not, for this it doesn't matter as much) and then explaining why they would not return (lifespan limits, self-destruct mechanisms, etc), there is some potential depending on how crafty the scripting is to rough out the edges to make it all feel germane and taut*.
But if it's the same species just making a return and a namedrop for no other sake... why? Let the sequel to the sequel address it. It's like a computer programmer is not going to go boot up MS DOS 1.0 and make changes to its source code, recompile, and create a new branch alongside or anything as everyone moved on to newer platforms that all had improvements and drawbacks, etc, etc.
* But that's why I've avoided prequels in general***, even ENT, they usually don't answer anything that needed answering, and the times they do it doesn't really mesh. TNG really got it right, setting itself decades in the future, and not bothering with big canon things because any fans that care can come up with their own connect-the-dots and that doesn't change the credibility of the continuing saga at all. Also, if ENT had a commander named Yarrow, would we have a Yarrow Alert as well as a Reed Alert? Dumb, yes, but now we got the origin to "Red Alert" apparently and that answered the biggestsy question ever that needed addressing for decades... That aside, the change in technobabble to describe ship functions and components was pretty refreshing at times so there's that...
** Which was more or less limited to Data being "fully functional", but at least they went from the sophomoric first instance to try to make it seem more credible and gave some emotional depth - from the viewer's POV. Which was pretty cool to turn lemons into lemonade as, often, the lemon is just buried or any attempt to improve fails, so there's that... then if it succeeds they wring as much of it out, hence Data's family tree and/or story about androids being people just like us too were getting more and more thin and dim with each passing story. But Lore succeeded and, you guessed it, it all spiraled out from there. Gotta have a sequel sometimes.
*** IMHO, YMMV, some dig 'em, some don't, even BSG04 had the acclaimed "Caprica" spinoff that some fans balked at because it didn't mesh (logistically to their universe's saga, or for them as viewers due to tone and/or other factors)...
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