My list:
Department stores - Venture, K's Merchandise, Service Merchandise, Zayre, Osco Drug, Revco (which became CVS, but not the same).
Restaurants - Spinnakers, Chi Chis, Master Wang's, Po Folks, Duffs, Morrison's Cafeterias.
B. Dalton, and Walden Books were everywhere. We had a mall that had a B. Dalton, and two Waldens (or the other way around).
B. Dalton sort of equals Barnes and Noble through corporate mergers. The same thing is true of Waldenbooks and Borders - which means they're all gone, anyway. I think the companies decided that department store sized book stores were going to be "the future!" and migrated in that direction... just in time for Amazon to take off. I'm surprised Barnes and Noble is hanging on.
I remember that RC Cola had an equal amount of shelf space in the grocery store as Coke and Pepsi.
It might be a regional thing, but this is still true around here. Well, close - I think RC has about a quarter of the aisle, and Coke + Pepsi have the other three quarters. But I'd chalk that up more to RC not having as many varieties more than anything else.
The sodas I remember when I was a kid were TAB and Shasta; they were EVERYWHERE. Now I hardly ever see them.
You can still get Shasta at Big Lots, but aside from there, it seems like the only places I see it (and there, I see a LOT of it) are at hospitals and nursing homes. (I do a lot of work at those sorts of facilities.) Seems like they found a niche market to cater to.
Babbages and Electronics Boutiques became GameStops. But I feel kind of sick even saying that. Out of our three GameStops in town, only one even has *a single end shelf* of PC games. :/
I miss Egghead. (Which is now Newegg.com, sort of - but not the same, either.)
I am surprised Kmart is still around.
Still around, and apparently thriving well enough to have been the big dog in merging with Sears a while back.
My first actual car which I never drove legally was a Pontiac and I used it as a down payment on a Mazda. No more Pontiac cars.
Ahem.
(But only kinda. They're at least officially licensed to do that by GM, though.

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I always thought that Piggly Wiggly was the weirdest name for a supermarket. When I would visit family in Spartenburg SC, we would always visit PW just to say we went there. However they had awesome customer service, would carry everyone's bags to their cars. Coming from New Jersey it was a weird sight to see.
I live in South Carolina. Still tons of Piggly Wigglys around here.
