My vote is no.
First and foremost a decision needs to be made as to the target audience of a TV series. All other direction descends from this. The NuTrek movies were directed at general audiences with the frequent nods to Trek fans. Translating this formula to TV is extremely difficult, mainly because general audiences have plenty of action and drama available outside of science fiction. I can't see CBS giving prime time to shows generally aired on lower tier networks like TBS, SyFy, etc. Superatural drama has made some headway here but not onto the major networks, not for prime time.
Recasting Enterprise crew now would muddle the fan base. "Who is the real James Kirk?" Snooze rest, plus, if they're thinking 5 year mission, I'd be VERY interested to hear how they'll avoid the mundane writing and 'been there before' approach that doomed Archer's Enterprise. Otherwise I only see this as the first best way to KILL NuTrek.
I don't believe the movie cast would agree to a TV series. Why not test the waters with a made for TV movie or 5 episode mini series? Let the ratings dictate whether a full run would work. Budget for this could be better too.
NuTrek Animated: this would be for hard core trek fans only and/or kids. I don't see this as a mainstream audience winner. Do we really want Trek for kids (Clone Wars)? I don't. LEGO Star Trek? Watching the LEGO Star Wars eps is good for laughs but doesn't move the franchise forward. It IS mainstream audience focused though.
The question boils down to how Trek will fare over the next two to five years as Star Wars returns in a BIG way. Relegating Trek back to TV will do exactly that, relegate the franchise to a secondary delivery channel. I think he better move is to keep Trek where it is, competitive on the big screen. Audiences WILL shell out for tickets to BOTH Star Wars AND Star Trek provided the two DON'T open the same weekend (or the same month).