Only two things have broken that I have noticed so far - Cyberduck (an FTP program) for which I understand there is a working beta version, and my mouse - Expose and Spaces can no longer be controlled from the thumbwheel. I gather from a bit of googling that an update should be soon (this is a Logitech mouse in case you were wondering).
The mouse problem on my iMac is sorted - it seems in 10.6, both Expose and Spaces have been moved to the utilities folder within the applications folder itself, so the mouse software couldn't find them. If you copy (don't move) those two applications back into the applications folder, my thumbwheel works again. Hurrah!
Still awaiting a non-beta Cyberduck version. I'm not too fussed though, as it is free software. When it's working properly, I'll make another donation.
I did note over the weekend that the Logitech software also played havoc with the trackpad on my Macbook. None of the finger gestures worked, other than the two fingered scrolling. So I removed the Logitech software, and everything is now fine. I can pinch and Expose myself at will.
Link to info.
So all my stuff (except Cyberduck) works. But then I don't run all the really fancy stuff.
What's the deal with all this incompatible software? This is not what I've come to expect from Apple.
As far as I can tell, it's not an Apple problem, rather other non-Apple developers not keeping up. Snow Leopard has been out a while for developers. But as noted by others, Vista had the same issues, but the issues with SL are much less. Most of the software works.
In other news, I've switched back to Safari from Firefox. 1 bump versus 10 on the dock on start-up. I'm so fickle.
