It's hard to see how it wouldn't be. It's an entirely new set of parameters to experience. Even if they were equivalent, they'd still be arrived at differently, & therefore perceived differently enough to be noticeable.So I suspect he would find the senses of a Soong android to be quite alien.
This is why a Soong android seems like a good fit for him, because clearly some of them do perceive themselves as flesh & blood. Is The Doctor so different? I'm not as up on him & his Voyager stories to know the ins & outs, but doesn't he in some way also interpret his physical existence as a real thing in some way, even though he is aware of his actual physical state? If not, then I guess it all comes down to the individual programming... which is mind boggling in its scope, to think how many varying degrees to which holographic AI might interpret their own tangible realityWhich brings us to Moriarty. He's a special problem, because he's a hologram programmed to think he's human.
What I mean is: when I eat a sandwich on the holodeck, the computer replictes a sandwich for me to eat. But when Moriarty eats a sandwich, the sandwich is an illusion and disappears as he eats it, but he thinks he's tasting it and feels full when he's done.
The computer doesn't do a chemical analysis of the sandwich and then tell his brain how tasty it would be, it just tells him "it tastes good".
Moriarty may be consciously aware that he is a hologram, but he perceives his own body as being flesh and blood.
I guess my feeling is that we don't know enough about how Moriarty perceives his environment to know if we can satisfactorily mimic it for him.
I should look up more about that mobile emitter of hisBut if you were to build something roughly human sized that was capable of projecting a hologram of sufficient sophistication around itself, that would suit him exactly. It combines the sensory experience of being a hologram with the freedom to go where the infrastructure wasn't built specifically to allow him to go there. Well, he's got the better version of that from the future, but such a device would apply to others of his kind.
That's a very interesting notion, I hadn't considered, & plausible, but how does that explain The Doctor? I shutter to think he is experiencing life in a different way than Moriarty. The notion could be as complex as every individual holographic AI is experiencing life in an almost unique way from one another, based on how they were programmed.Lastly, I don't think Moriarty was just a result of Geordi mis-speaking when asking for an opponent. The computer of the Enterprise D was unique because of the things the Binars had done to it, and one of those changes made holodeck characters much more realistic. While whatever had allowed the creation of Minuette stopped working after the Binars returned the Enterprise, apparently enough of it was left to allow the accidental creation of a character who was self-aware.

Great post btw. So much to think about there
