4th wall Tostadas

[Orion Pimp]

Then there's the classic from TOS :
Colonel Fellini -"I am going to lock you up for 200 years..."

Kirk looking directly at camera -"That ought to be ... just about right..."

 

[Ethros]

Tuvok to Paris in Worst Case Scenario-

"If you think I will allow you to turn this program into a parody, you are sorely mistaken."