^Well, if you're not interested in the speculative elements, why do you want it to be in space at all?
I'm interested in the speculative elements, but in the same way that Firefly or BSG are. There are still sci-fi elements, but they aren't necessarily at the forefront of what the story is about.
I'm still thinking Chindi here....
The Pip and Flinx books are terrific, and if you enjoy a bit of creepy-scary stuff, I recommend Midworld and Mid-Flinx.