Then we'd have to ask what a cultural icon is. I don't recall any of the villains mentioned here except Cruella de Vil and Ursula reaching that sort of status (Frollo's been sort of forgotten, for example)..
The definition given by Wikipedia seems accurate:A cultural icon can be a symbol, a logo, picture, name, face, person, building or other image that is readily recognized, and generally represents an object or concept with great cultural significance to a wide cultural group.By that definition, I think we could include the following animated Disney villains among a list of cultural icons:
Formerly, Shere Khan, Kaa, and Monstro would probably have counted among the iconic Disney villains, but their movies have faded somewhat from the public consciousness. Frollo and Hades may or may not be iconic; it's hard to say; their movies fared poorly, but they appear to be relatively widely recognized (Frollo seems to have enjoyed a Youtube afterlife due to Hellfire).
- Queen Grimhilde
- Maleficient
- Cruella de Vil
- Captain Hook
- Jafar
- Ursula
- Gaston
- Emperor Zurg
Interestingly, the iconic Disney villains are those merchandised most easily and widely. There's probably a connection.
Let's not forget Scar.
