So many but one of my favorites is the last scene in Angel's "Not Fade Away"
Angel had several moments that hit you like a ton of bricks and continue to do so on repeat viewings. Many of them involve deaths.
Doyle's death in "Hero." "The good fight, eh? You never know until you've been tested. I get that now. ... I guess now we'll never know if this is a face you could learn to love."
When Lindsey & Drusilla come in to re-sire Darla in "The Trial." "How did you think this was going to end?"
Angel getting the phone call informing him that Cordelia died in "You're Welcome."
Fred's death in "A Hole in the World" & the final shot of her driving into the sunset in "Shells."
Even after Fred died, the pain didn't stop there. Joss twists the knife when he has Illyria impersonate Fred in "The Girl in Question" & "Not Fade Away."
On
Buffy the Vampire Slayer, when Xander asks Buffy to the prom in "Prophecy Girl." Even though I knew what the answer would be, it still breaks my heart because I believe these two characters should be together.
Also in "Prophecy Girl," Buffy's breakdown when she learns of the prophecy that she's going to die.
On
NewsRadio, the scene in "Who's the Boss, Part 2" where Dave learns that no one on the staff voted for him to be boss. Even though it was played for laughs, whenever I feel particularly stunned & rejected, this is the scene I always come back to.
The 5th season premiere, where we see the aftermath of Bill's funeral.
Another scene I often relate to is in the 2nd episode of
Homicide: Life on the Street, where Bayliss complains about not having a desk. I often felt this way at my old job, that I was completely overworked, underappreciated, given an impossible task, and not even given basic tools with which to do it.
In the
Frasier Season 7 finale, Niles confessing his feelings to Daphne.
Odo & Kira's first kiss on
Star Trek: Deep Space 9.
On
Doctor Who, the separation between the Doctor & Rose in "Doomsday." (Then "Journey's End" had to come along and spoil it!)
John Smith's vision of the future life he might have if he stayed human and married that nurse in "The Family of Blood." And then that bitter scene at the end where she asks him, "If the Doctor hadn't decided to come here on a whim, would anyone here have died?" It's rare that the show really examines just what kind of devastation the Doctor's travels can cause.
From an early
Simpsons episode, "The Way We Was"...
"Homer, why are you doing this to yourself?"
"Because I know we were meant to be together. Most of the time when I have a thought there are a lot of other thoughts in there. Some things say yes. Some things say no. But with you, there's only yes. How can the one thing I've ever been sure of in my life be wrong?"
(Some day, I hope I get the chance to say this to the woman I love.)