The first question to ask, is; 'Exactly what is an ion drive?'
It isn't what you think. It is not the conventional ionizing of matter. That doesn't make sense at all.
However, what does make sense is that some "low" level source of extreme energy is introduced into a reaction medium. Let's say water, or it could be NH3, or CH4...the point being something easily obtainable.
So, now about that energy source.
Fission, Fusion, Isomer. Three different nuclear reactions. Isomer is in reality the most problematic. Because it requires a gamma ray pulse to initiate. Tylium from either Battlestar Galactica, is most likely this type of reaction.
However we are talking 'Star Trek'.
So, in the early days of star flight, just how much did even one gram of antihydrogen cost???
In other words, a question of scaling for economics. Antimatter will be very expensive during the early years...
So, keeping costs low is a requirement.
So, you start out with a Fusion reaction, then add in enough Antimatter to make the higher warp factors possible. Microscopic amounts - very microscopic amounts. Enough to take a Fusion warp reactor and take it to warp factor four capability. In other words a doubling of the energy, in other words Ion power.