Unlike most Star Trek shows, Picard kind of jumps around with its main setting. For the first two seasons, we got the La Sirena along with a few appearances in S3, but I forget what happened to the ship. S2 is bookended with the new Stargazer and S3 features the Titan-A. Finally, we bowed out the series with the Enterprise-D. Which was your favorite?
EDIT: I voted for the La Sirena. It was the first ship the show focused on, spanning 2 of 3 seasons. I loved Picard and friends operating out of this little cargo ship that no one in their right mind would take seriously.
Crashed it in S1, crashed it again in S2.
Whish it got a better send-off in S3. If I remember right, Worf and Raffi beam over to the Titan-A, and... the ship just got forgotten about. 
EDIT: I voted for the La Sirena. It was the first ship the show focused on, spanning 2 of 3 seasons. I loved Picard and friends operating out of this little cargo ship that no one in their right mind would take seriously.




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