The last shot is him just wandering off to continue his quest.
Honestly, I don't think the show was very good. A LOT of standard action/chase scenes, a few 'meaningful' episodes where we're told that hippies are really good people at heart, and Native Americans deserve fair treatment, even if the main one is played by a Sicilian (Sal Mineo) (seriously). His immortal blood was mainly a McGuffin, and only played a real role in 3 or 4 episodes where he used it to heal people. Oh, and the opening title sequence is unbearable - two full minutes, half of which is Paul Frees narrating the premise, half of which is chase scenes with music mixed so sharp it literally hurt my ears. I'm glad I finally saw it, but I have no need to see it again.