the back to back Borg incursion and Dominion War should be a screaming alarm that the Federation must embrace augmentation at last. The next threat, Breen or whoever, will not be as reactionary about it. Bashir is the case for augmentation combined with holographic interspecies beings. It was centuries since Khan and the Eugenics wars, in that time, advancements and understanding could have improved, but Federation was naturally more occupied consolidating their member worlds into a single interstellar society. Having done that, they must move beyond.
I think post-Voy, the Federation has reached its "sleeper must awaken" point.