There's probably too many things to list, but here we go:
* The most glaringly obvious problem, and the one that makes the series irredeemable for me, is that this is an action show when it's supposed to be about exploration, science, diplomacy, and moral dilemmas. I gave JJTrek a pass for this, but in a TV show I expect meat and potatoes, not just ice cream. The captain saying "we're explorers, not soldiers" doesn't mean a damn thing unless we actually see them doing exploration, rather than just firing photon torpedoes at people.
* The series seems to revolve entirely around Michael. She's the Mary Sueiest character I've ever seen. Every single event in the story revolves around her decisions, her feelings, her burden to protect her crew from their own decisions, etc. Obvious author self-insert is obvious. I think she's actually a pretty decent character, but the rest of the ensemble needs to get some attention. She got sentenced to life in prison at the end of the episode and then she's out again in the next episode - give me a break. How about some realistic character development, not a soap opera.
* Unearned faux-dramatic moments. We don't know these characters well enough for any of the over-dramatic bullshit to be interesting. Captain Georgiu is dead - boo hoo, I knew her for, what, 45 minutes? Michael mutinies against her captain in the first episode - again, why do I care? I don't know anything about either of these characters or their relationship yet, so the betrayal means absolutely nothing. For all I know, Michael throwing a fit and neck-pinching her captain is an everyday occurrence.
* The general stupidity and shallowness of the plot. The Vulcan answer to dealing with the Klingons is "shoot phasers at them first so they don't attack us!" What? That's the best we can come up with? The entire two episodes reduced down to one battle between a bunch of ships and then a phaser fight. It's a fanfiction-level plot. I expected more.
* The Klingons. I'm going to ignore the superficial changes because that's just a matter of taste. But they've also been turned into blood-thirsty one-dimensional maniacs, which is boring. I don't want to see ISIS in space. Not in a Star Trek series.
* The dialogue was cringy, with excessive banter and "witty" comments filling every single moment throughout the first episode. It was just wayyy too much chit chat and none of it very memorable.