If you are using science fiction as your model for reality, understand that in science fiction, they have infinite money. Economics is seldom an issue. The hurdles of sending things out into space is mass and time, and much capital you can spend to overcome them. So we use robots. It's true now, and will be in the future. Money, or the exchange of value, will always be finite.
If and when humanity decides to colonize a distant world, robots go first. Humans won't follow as people or passengers, but as embryonic cargo.
That may not be the method anyone favors, but it's more likely, as it is the most affordable.