My personal hope would be to see the NX-01 pulled out of mothballs and refit in the Drexler style.
Unfortunately, canon makes it pretty clear that NCC-1701 was the first Federation starship named
Enterprise. I tried to think of a way NX-01 could still be in service as a non-commissioned ship or Earth ship, but if it were spaceworthy for those purposes, why not commission it as a Federation ship? And I'm tired of secret missions unrecorded by history.
As for the Drexler refit, it occurs to me that, despite what the cover art shows, it's never specifically stated in the
Romulan War books that NX-01
wasn't refitted that way.
And there are always other ships...