Back in the time it was aired, everyone sort of shrugged off the idea that the Brekkians were drug lords who had the Omarians addicted to their space smack. It wasn't really something that had a real life analog and more fans focused on Picard's use of the Prime Directive than the social satire. However, I'm from Kentucky and the opioid crisis is something that directly affected my community where companies massively oversold drug medication to the public while lying about the addictiveness as well as risk. So, instead of drug lords, the Brekkians work very well representing the Sackler family and other groups. Especially since the Omarians kind of give off that rural working class vibe.