Alright Im gonna borrow from BSG, and apply the idea to star trek. Make the show a hard sci fi version of star trek, with no aliens no ftl, transporters, force shields, artificial gravity, sub space commuication or other unknown techologies and stick to ones we know likely to exist. In not too distant future earth developes an advance knowledge of human genetics, nuclear fusion, and advanced computing techologies. Genetic engineering becomes common place, augmented humans attempt to take over the world in a great eugenics war. Towards the end of the war, and nuclear fusion expert zefhrane Cochran, develops the nuclear propulsion technologies allowing for a mass colonization of the solar system. upon the end of the war, a unified planetary federation emerges. With strict laws governing the use of genetic engineering i.e. the prime directive. . As a consequence of laws, many augmented peoples are expelled from earth to orbital colonies around the asteroid belt. The initiates the ;last contact; between augments and earth. 2 centuries after the events of last contact, the planetary federation now a utopia is sending out a wave of exploration missions to the long forgotten augment colonies. With each colony having to deal with a unique survival scenario, diverse genetic adaptions, and philosophies occur. Aboard the nuclear propulsion vessel Enterprise a captain jame t kirk sets out on a five year mission to seek out these colonies. After nearly 2 centuries of federation mandated isolation, it appears these colonies have developed into societies of their own. With several augment groups fighting for dominance of the solar system. It appears the most deadly of these groups are the descendants of cardassia colony, kronus colony, and romulus. Seeking allies from more pleasant colonies, such as betazed, orion colony, vulcan, bajor, and andor, the federation seeks a great solar Confederacy.