The problem is, that's an EXTREMELY meta-fictional question, as you're asking about the possibilities of a genre of fiction within it's own genre. There are a few things you can extrapolate, though, give the historical progress of our own science fiction literature.
Many of the sub-genres of what we now call Science Fiction existed in the 19th century before the term was ever formalized. Particularly within the oeuvres of H.G Wells and Jules Verne, who, between them, explored space travel, time travel, alien invasion, genetic engineering, and many other fantastic possibilities... The problem was, though, that, with so little of the actual SCIENCE unknown at the time, it allowed a lot of room for imagination to fill in the gaps, as it were. As the 20th century wore on and new discoveries were made, and things like quantum theory and Relativity become fairly close to generally known of, if not quite understood, the rules for proper SF rose sharply. Things that once made for great stories, like life in the Solar System or the unlocked potential in our brains, etc. have fallen from favor as the real science just doesn't support that kind of thing if you're going to write it seriously. As a result, SF has become much 'harder' than it used to be, a trend I can only see continuing into the future, since we're still discovering new ideas and concepts about the universe we live in. One has to wonder, if there will come a time when enough science is understood that Science Fiction will no longer have any room to wiggle... Or else, if the trappings of science fiction become so commonplace in the real world that it ceases to be fiction anymore but just a standard literary setting... I mean, a story involving aliens, Faster than light travel or other universes wouldn't really be considered Sci-Fi in the Trek 'Verse, as there, these things are established facts, not vague theories or just plain impossible...
Though one does wonder what SF of the 24 1/2 century would even look like...
