However, it is possible to imagine a scenario of an alien invasion that is fightable and winnable. If a generational ship arrived expecting an uninhabited world to settle and found it occupied, they could conceivably have a leadership or culture that would (or feel desperate enough to) want to conquer or destroy us. Since they would have limited resources and be without a dedicated military, they would have to improvise. This would be an interesting scenario for a novel.
Closest thing to that I've seen done so far is the Scrin storyline in Command & Conquer 3.
Well, it sounds like they just underestimated the tech level, like in the Turtledove books. I'm talking about a one-way generational ship that gets here expecting to find a vacant piece of real estate-- instead they find six billion people. What do they do? They can't go back home. If they decide to exterminate us and take the planet, their superior technology will make them a threat, but their small numbers and limited resources will keep the odds even.