NO SPOILERS FOR THE FINALE PLEASE!!! 
So, a few episodes ago, Ted teared up when Mother said what kind of mother would miss her daughter's wedding? This lead many of us to dread that Mother dies prematurely before Penny gets married.
Me, I vote for misdirection. They're trying to fool us. They're not gonna end on a downer.
The other dark horse choice is Mother is dying of cancer or some other disease, and they think she's going to die, but she ends up surviving.
So... vote who you think is going to die... not who you think should die.

So, a few episodes ago, Ted teared up when Mother said what kind of mother would miss her daughter's wedding? This lead many of us to dread that Mother dies prematurely before Penny gets married.
Me, I vote for misdirection. They're trying to fool us. They're not gonna end on a downer.
The other dark horse choice is Mother is dying of cancer or some other disease, and they think she's going to die, but she ends up surviving.
So... vote who you think is going to die... not who you think should die.