The recommended dosage on the bottle, two 200mg pills every four hours, is 20-percent of the prescription dosage, which is two 1000mg pills every four hours. House isn't stupid; he's not going to OD on OTC Advil.If nothing else, he did seem to be taking an awful lot of ibuprofen, probably beyond the maximum recommended dosage. If so, he's putting himself at increased risk of gastric bleeding, heart attack, or stroke.

And House's philosophy is probably not that dissimilar to mine (and that of some friends of mine) -- take the large doses and deal with the pain now, and deal with the damage the large doses can do later. (When I've had very bad migraines, I've been known to take aspirin, Tylenol, and Advil near-simultaneously; I'll take one, then ninety minutes later take the next, and so on. Wise? Probably not. Deals with the pain? Absosmurfly.)