I for one would like to see it happen. I liked the Ben Affleck one outing and was looking forward to another one but George Clooney has proven he can be an action hero with Three Kings, Syriana, and Michael Clayton so I think he can pull off a Jack Ryan film. Maybe in the ilk of Alec Baldwin's portrayal from The Hunt for Red October.
http://www.mania.com/george-clooney-jack-ryan_article_116129.html
http://www.mania.com/george-clooney-jack-ryan_article_116129.html