I think some of the ideas would have worked. That version of Starbase 1 was used in the books, IIRC. T'Pol's father being Romulan would have dovetailed nicely with the retconned plots Trip was involved in. Denobula, Stratos, the Kzinti, and Flint could easily work with the novels. The Alice Krige version of the Borg Queen could have worked with Star Trek: Destiny (perhaps as an improved Queen avatar).
Shran would have been much harder to work in, though. The novels probably could have worked him in, though, going back to Andoria to participate in a sheltreth and then returning to the Imperial Guard as a liaison with Starfleet.