According to Memory Alpha, the writers of XI (or as RLM puts it: Star Trek, The, urr, Star Trek) were 'inspired' by some of the TOS novels when writing the script. The two they reference specifically are Spock's World and Prime Directive. After reading the summaries for both novels, I think Spock's World's influence on the movie is obvious (its about Spock.. and his world). Prime Directive's influence is less clear. Other than the destruction of an alien planet (for very different reasons), the two stories have very little in common... Unless its influencing another story down the pipeline. Given the nature of the movie industry I have no doubt they were already brainstorming plot lines for the sequels while working on XI. I haven't read Prime Directive, but the plot of it could make for one exciting epic movie.
A lot of people here are still rankled by Kirk's sudden promotion. I think if Prime Directive were done as the follow-up it would address that criticism in a dramatic and interesting way. Basically, Kirk is accussed of causing the destruction of an alien world. He has to clear his (and his crew's) name and then face the real threat behind the disaster. I think him dealing with failure, getting thrown out of Starfleet and then fighting his way back to the captain's chair would make a great character arc and movie.
A lot of people here are still rankled by Kirk's sudden promotion. I think if Prime Directive were done as the follow-up it would address that criticism in a dramatic and interesting way. Basically, Kirk is accussed of causing the destruction of an alien world. He has to clear his (and his crew's) name and then face the real threat behind the disaster. I think him dealing with failure, getting thrown out of Starfleet and then fighting his way back to the captain's chair would make a great character arc and movie.