I've always loved the Fantastic Four. My first super-hero comic purchase ever was an early John Byrne issue (232-ish?), a Human Torch solo story called "Mission For A Dead Man".
The movies are really hit and miss. Not as bad as some like to say, but not really all that good either. Gruffudd's Reed Richards was passable. Chris Evans as the Torch and Michael Chiklis as The Thing however were pure genius. Jessica Alba's Sue didn't really work in a lot of ways that have nothing to do with Alba's performance, but just that she was mis-cast in the part.
Where the movies really screwed up bad was with Victor VonDoom. Written wrong, cast wrong, performed wrong and just all around wrong wrong.
For my money, as badly written, acted, and produced as the Roger Corman Fantastic Four movie from the 90's was, as 50's retro as the "special effects" were, it was a far better adaptation of the source material than the more recent blockbusters. I would love to see what they would have done with a real budget (the movie was made for a mere two million bucks!).
I'm really enjoying Johnathon Hickman's current run on the book. I'm loving the sub-plot (soon to be the main plot) involving the Richards' kids, Franklin and Valeria and "The War of the Four Cities". Valeria really is an interesting character, despite only being two-ish.