I agree about the Julian-Ezri relationship. I don't know that I'd call it the biggest misfire, but it is an annoyance in the otherwise mostly excellent final episodes. I never really got it. I know people say, "well, now Bashir can be with Dax!" but that is exactly what I don't like about it. Ezri is a person, not a consolation prize. It didn't help that I found Bashir's pining over Jadzia annoying rather than poignant, or whatever the show was going for. When he and Quark got all mopey over Jadzia wanting to have a baby because that meant she was happy with Worf, I was thinking, "wow, you guys are shitty friends." Which, I expect that from Quark, but it felt like Bashir was being rewarded for that in the end, and it just rubbed me the wrong way.