Well from a technical point of view we now how to simulate gravity on a spaceship, you'll have seen the method in films like 2010 and shows like B5, where part of the ship rotates.
http://en.wikipedia.org/wiki/Artificial_gravity
Astronauts in space for weeks to months can run into trouble. Calcium in bones secretes out through urine. As the bones weaken, astronauts are more susceptible to breaking them if they slip and fall, just like people with osteoporosis. Muscles also lose mass.
Astronauts typically exercise two hours a day in space to counteract these effects, but it still takes months of rehabilitation to adjust on Earth after a typical six-month space mission. More recently, doctors have discovered eye pressure changes in orbit. NASA has tracked vision changes in astronauts that were on the space station, but nothing so serious as to cause concern.
An advantage to rotating sections, is that you could rotate them at different speeds to siulate different levels of gravity.
Or like what was shown in 2001: A Space Odyssey, with the Discovery?
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