The premise is that a bunch of people on a small, insignificant ship are thrown to the other side of the Galaxy. Even though the same thing happened to Kirk and Picard with both returning home easily, these guys can't (an early sign of incompetence). The premise says they will never have any support, meaning no one will EVER help them in ANY way because it would violate the premise. Doing so is a betrayal of the premise and unforgivable. The crew is made up of two groups who are nominally opposed, but really don't have enough in the way of differences for it to have any impact on the show. Since they are just one tiny insignificant ship with an insignificant crew (no one famous, no "chosen ones", no God-Humans, no Flagship personnel) nothing they do can be of any real importance on the Galaxy or the Delta Quadrant's well-being because doing anything would make them too important for one tiny insignificant ship. And since they're always moving they can never stay in one place without getting complaints no matter the reasoning, meaning they'll never be able to introduce recurring characters or give their new aliens the time they need to be better developed. And since the crew are all alien to the Delta Quadrant they have no connection to local affairs meaning there's no dramatic potential there either. Being an insignificant tiny ship also means they can't introduce anyone tough because a tiny insignificant ship can't beat anyone, so the only option is to constantly run away like spineless cowards from everything. See folks being attacked by space pirates? Well too bad, we're too insignificant to do anything so we'll just run off and let innocent people get slaughtered because we're too chicken-sh*t to try anything. That is the premise of Voyager.