Not in principle, no. I don't understand calculus, but this is not because calculus is fundamentally not understandable. Then again, I'm a positivist. And mysticism can work. Take for example the Invisibles or The Filth, two of Grant Morrison's best works--that stuff is a mess, but it works on a mystical level, and never really cops out with mysticism as a means to explain key plot points. Mysticism did not work in this instance, for precisely that reason, and others.