You may want to add Sisko and what he did in "The Pale Moonlight" and Janeway and what she did in "Scorpion". It's hard to maintain the highest quality of morals when you are on the losing side of a conflict. Laws and standards people/characters swore to uphold become blurred and or bent; when self-preservation is taken in to account. The conflict and or war becomes about who can tear their opponent down fastest. Section 31 played the long game with the morphogenic virus. In the event of the Dominion conquering the Fed. The government could use the cure as a bargaining chip if they were to discuss terms of surrender. The Federation Council and Starfleet's first directive was to protect themselves and their citizens. It's ugly but from the Fed pov, they were in the right. Helo sabotaging the air system to kill the infected Cylons is different. Like Picard, Helo was uncomfortable using people as a biological weapon against an entire population. Laura Rosalin was interested in the self preservation of the human race. She was callous and dismissive of Cylons as people. Even Bill Adama tried to pass the buck on this decision. He didn't like it but he would still carry it out if ordered. If Picard in "I Borg" knew everything we would discover in VOY season 3-7 and the film FC. I think his decision would have been to use the Hugh as a weapon. Janeway formed an alliance with the Borg to created the nano-probe torpedoes. She used them to destroy dozens of Species 8472 ships. We saw the the effects her decision in the episode "Hope and Fear". Janeway defended her decision by arguing ignorance of the true circumstances of the conflict. That and her own self-preservation directive to get her crew home. Sisko assisted in an assassination the the creation of a ruse in order to bring the Romulans in to the war. This caused the Romulans to break their non-agression pact with the Dominion and join the Fed and the Klingons. However it also cost the lives of tens of thousands of Romulans. Romulans who died in a conflict based on a lie. All of this was done to preserve the Federation. It would seem self-preservation trumps morals in extreme circumstances.