There are several things about putting the crew in the DQ that limited them. Besides the fact that they had already established that travel across the galaxy did not take 70 full years in various TOS and TNG episodes. The DQ gave them the major production issue that they shouldn't have ever seen the same aliens more than once of make detours to people's home worlds just because they would never be in the same area of space twice. What if they were in another galaxy though, knowing that if they wanted to fly home in a straight line it would force them to travel through the uninhabited space between galaxies, which they know they can't do without refueling? Then they wouldn't be able to assign a distance and divide by 1000 to get the number of years it would take to get home. They would have been forced to nest, to learn how to play local politics and adjust. Their hope to get home is finding a new technology that is better than warp or a spatial phenomenon, something unlikely enough to make crewmembers despair more and consider just quitting. One of the reasons The Void is one of my favorite Voyager episodes is because it is the kind of situation this premise would have had to force them into. And they could have still done Borg stuff. The Borg weren't definitively established as being from the DQ until Scorpion, the Borg could have just been in that galaxy instead.