Sorry, how would this have any effect on River? The Ponds are zapped back in time, meet and adopt the newly regenerated Melody as a toddler, and raise her in Leadworth. She grows up as Mels, not realising her adoptive parents are also her best friends at school. She then meets the Doctor as seen in 'Let's Kill Hitler', regenerates into the Alex Kingston version, and gives up her remaining lives to save the Doctor. Her life then progresses as we have already seen. As I say though this is all speculation. Another twenty four hours and we will know.