Set your own goals for NASA

[StarryEyed]

Begin development of a space elevator. Get cheap, safe and reliable access to orbit and everything else will follow.

[arch101]

Mass production of Aries I and V and Orion vehicles. The cost and reliability of getting to orbit will only mature to a level of being relatively cheap and routine with frequency.
Once orbital flight becomes reliable, all longer range goals are possible. Aries V can launch components of space stations and large manned vehicles capable of exploring the planets and exploiting the Moons resources.
It all hinges on making getting up there and getting back easier and more reliable.
As long as a single spaceflight is a much-delayed, ultra delicate, billion-dollar-a-shot event, all longer range goals are simply out of reach.

[The Squire of Gothos]

Lindley said:Long-term: Identify exploitable resources elsewhere in the solar system. Once such are found, the rest will follow.

Hmmm...

1.) Find resources.
2.) ????
3.) Profit!