For me, too. And De Kelley's delivery of this speech was just sublime. Another favorite, from Charlie X, when Kirk tells Charlie: "There are a million things you can have in this universe and a million things that you can't have. It's no fun facing that, but that's the way things are!"
From STID: Spock: I am expressing multiple attitudes simultaneously. To which are you referring? Kirk: Mr. Chekov, did you break my ship?
Here's a great conversation concerning the transporter. Pulaski: Captain, if this hadn't worked? If... Picard: It would have been necessary to beam your energy into empty space. Pulaski: Why should I be concerned about having my atoms spread across the galaxy? I imagine that's what's going to happen every time I get into the damn thing. "Unnatural Selection" TNG
How about this one which sums up Spock and Kirk Edith Keeler to Spock: "You? At his side. As if you've always been there and always will. "
I actually liked Pulaski a lot more than Crusher. Maybe it's because I started watching TNG during the second season, but although she's a poor man's McCoy, she has more personality than Beverley, who basically never did anything except being the ship's doctor.
^^^That actually is a pretty powerful quote. It shows just how pathetic and desperate that character is.
PICARD: Headache. Headache. Surely you know what a headache is. CRUSHER: Of course. But I don't often encounter them. From "The Battle" (TNG). I find that one hilarious, because, sure, The Federation has very advanced medecine, but in order to eliminate headaches you'd have to alter the human body, which means genetic engineering, a big no-no in the Trek universe.