The 2D artist known as Reverend did a design based on a small colony ship only partly seen landed and overgrown with vegetation in the DS9 2nd season episode "Paradise". Not sure if those images are still out there, but I have some saved. Give me a shout if you want em.
The Reverend's Santa Maria
exterior view can be found by googling:
Did Kris ever do an interior? I'd very much like to see that. The design is rather limiting, cobbled together as it was from runabout set and prop elements; just thinking about packing a colonyful of people and their vital supplies in there gives me claustrophobia.