As long as Sony doesn't feel the need to reboot after the third one this time.
It probably depends on how well the Sinister Six and Venom spin-offs do.
I know they've stated they want to do those, but I'll believe them like I will when the Superman Returns and GL announced sequels were mentioned.
I'm frankly not positive TASM2 is going to have domestic legs. Likely to open fairly well but I'm not any more optimistic about this than I was the first one, less so actually.