In at least two episodes (The High Ground & Attached - maybe another) Crusher and Picard are in life or death situations, and she tells him, "Jean-Luc, I have something to tell you..." A friend speculated that Wes was actually Picard's son from a fling they had when she was still with Jack. They never resolved what it was she wished to tell him. In the non-canon book Q-Squared, there's a plot line in which Jack is still alive and captain of the Enterprise with Jean-Luc as his XO. Beverly, separated from Jack, joins the crew as CMO and she and Picard rekindle the torrid affair they had years ago on the down low. Excellent story.
"With the first link, the chain is forged. The first speech censored, the first thought forbidden, the first freedom denied, chains us all irrevocably." -- Judge Aaron Satie