There is no chance that they would use Khan again in the next film.
Damon Lindelof wrote:
To answer that question would be to determine whether or not he actually survives this movie, but if he survives this movie, I think that we would be incredibly stupid to not use [Benedict Cumberbatch] again.
Into Darkness was the most financially successful overall and second most profitable movie (after TMP) in Trek. Bringing back Khan for more makes financial sense.
BUT, I suspect Cumby's rumoured role as the big villain in Star Wars VII, VIII and IX will prevent his return to Trek.