You mean, aside from Nanietta Bacco dying, the Andorian species being saved from extinction, Bashir being drummed out of Starfleet and branded a criminal, White-Blue being revived, Kellessar zh'Tarash being elected President, and Starfleet launching a huge new exploration initiative?
Bacco is replaced what seems to be a Bacco clone.... who has less personality. Of course the Andorians would be saved. Who would ever think otherwise? Bashir will be back in some way, shape or form so nothing big there. I don't follow Titan so I could care less about whoever White Blue is... and it seems minute compared to the grand scheme of things. Starfleet's exploration will last until the next big crossover so nothing big there. All in all, the story is a reset button