I think this is my fourth or fifth playthough. It's my full renegade engineer and I've decided that it's going to be a "kill everyone possible" playthrough. She'd already killed Mordin, sabotaged the genophage, gunned Ash down, Thane just died and because Eve lived I think she has an unpleasant meeting with Wrex in her future. I think the hardest thing is going to be Tali...not looking forward to that.
If nothing else the Citadel party ought to be interesting...if a little quiet.