Also, I have to wonder if the timeline really matters at all.
The only point of the NuTrek reboot was to bring back Kirk & Spock & the gang. If there was a new ship and new characters, how much would really change if it was set in the 23rd or 24th or 25th centuries?
The exploration stories would be the same
The alien of the week stories would be the same
The colony in danger stories would be the same
The Klingon stories would be pretty much the same
The Romulan stories would be the same, except Romulus blew up
The technobabble might be superficially different, I guess
My gauge of fan sentiment: Over the years a lot of people always wanted there to be some follow-up to Deep Space Nine, and are disappointed they never got one. But if they did bring back the Prime Universe, it's really unlikely they would reference the space opera politics of DS9 very much. It was somewhat complicated and obscure even when it was on the air, and that was a long time ago.
I suppose in the Prime universe, you would be more likely to see Cardassians and Ferengi, but they would be in the Nu Universe as well, along with Andorians and whoever else the writers wanted to use. Other than a few throw-away lines here and there, there probably would not be much if any difference between a Prime show and one set in the NuTrek reboot.