The season 5 "Dr. Bashir, I presume" genetic engineering doesn't jive with earlier episodes.
Just take season 2's Melora episode where he's helping Pazlar try to go without her wheelchair.
In the season 2 ep, he confides in her that he wanted to be a tennis player but after getting into the professional leagues, the first person to serve on him, he didn't even see the ball and he knew he was hopeless outclassed. So, okay, he may have been covering up enhancements there but why go into Tennis in the first place?
Second, the one that does bother me is that in S2 he mentions his father was a federation diplomat to Invernia II. Then in season 5, Richard Bashir gets downgraded to a complete loser who exaggerates having been a captain when he was really a III class steward on a shuttle run. But he never once mentions having been a diplomat when he could have.
Memory Alpha chose to keep him being a diplomat. But Federation Diplomats in previous eps were never losers, they were distinguished people not chosen at random. There is no reason for Bashir to lie about this in S2, because people can look up info easily, he himself would have known the truth if it was a lie.