Anyone remember the NYX comic mini series? I think that could be the basis of a pretty good TV series.
Not sure where the rights to it fall though. I mean technically it's about mutants (one of the characters is Wolverine's teenage, female clone....yeah) so it may fall under X-Men and therefore Fox. On the other hand they're all original characters. X-23 could be there without explicitly exploring her backstory.
But yeah, a Punisher series would be great if done right. Say for example, like this!