EDDINGTON: Do you realise what you've done?
SISKO: I've only just begun. I'm going to eliminate every Maquis colony in the DMZ.
EDDINGTON: You're talking about turning hundreds of thousands of people into homeless refugees.
SISKO: That's right. When you attacked the Malinche you proved one thing, that the Maquis have become an intolerable threat to the security of the Federation, and I am going intend to eliminate that threat.
If there were a hundred worlds which Sisko could quickly target and fuck up, that would still mean that there's thousands of Marquis on many of those planets.