The Borg would be awesome, so long as they ditch the Uncle Fester makeup and rubber costumes. Instead use CG to replace body parts with working machinery, take inspiration from Shatner's The Return
(much more variation, nonhumanoid drones, organic machinery, an Escher-like Hypercube station in transwarp space) and crank up the horror factor.
Imagine a Borg drone without a lower jaw, skin almost mummified, with a totally mechanical arm with joints in unnatural positions and moving parts where intestines should be. The only issue would be keeping the Borg from being so grotesque as to crank up the rating and limiting the audience.